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Yessi Pratiwi — January 15, 2008 / 11:18 pm
Harvard Medical School researchers have now identified 273 human proteins required for HIV propagation. They decided to take a different approach centered on the human proteins exploited by the virus, because they thought that antiviral drugs are currently doing a good job of keeping people alive, but these therapeutics all suffer from the resistance problem.
Over the last two decades, labs around the world have made impressive contributions to the understanding of the HIV life cycle, they’ve identified dozens of human proteins, or host factors, required for HIV propagation. The new study builds on this work, essentially quadrupling the list of host factors to include proteins involved with a surprising array of cellular functions ranging from protein trafficking to a type of programmed cell death called autophagy.
The researchers, led by Abraham Brass, placed the siRNAs (short interfering RNAs ) on thousands of human cells. Next, he unleashed HIV on the cells. If HIV replication was inhibited in a given well, it suggested the missing protein was involved.
Immune cells–the very cells HIV attacks–contain high concentrations of many of the 273 host factors, offering further proof of the list’s validity. The researchers hope, they might be able to tweak various parts of the system to disrupt viral propagation without making their own cells sick. Adapted from materials provided by Harvard Medical School.
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