You're here: My Health Blogging » General Health » Article: Identification of New Protein in Autism
Yessi Pratiwi — December 6, 2007 / 9:32 pm
Autism is a kind of neurodevelopmental disorder. It is a complex brain disorder that inhibits a person’s ability to communicate and develop social relationships.
Researchers from the RIKEN Brain Science Institute in Japan demonstrated that mice lacking the protein CADPS2 exhibited autistic-like characteristics. They show that mice lacking CADPS2, which is encoded by a gene in the autism susceptibility region of human chromosome 7, had impaired social interactions hyperactivity, and decreased exploration of a new environment; all of which are characteristics of individuals with autism.
An abnormal form of CADPS2 mRNA (which is an intermediate in the conversion of the CADPS2 gene to CADPS2 protein) was detected in some individuals with autism and was never detected in their healthy immediate relatives, leading to the suggestion that defects in CADPS2 function might predispose individuals to develop autism.
Before this, Nature Genetics published the findings of neurexin 1, part of a family of genes that plays a role with the neurotransmitter glutamate, which has been previously linked to autism. A gene on chromosome 11 that may be linked to autism susceptibility was also found. So, it could be said that several genes have been associated with the development of autism.
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August 4th, 2008 at 5:07 pm